Discovery of Mycobacterium tuberculosis protein in animal gene silencing

Release date: 2008-01-08

Discovery of Mycobacterium tuberculosis protein in animal gene silencing
American researchers in the journal Nature Medicine said that tuberculosis infects the human body, and the most important thing is that it can escape immune surveillance. If you can understand the mechanism and limit the spread of tuberculosis, it will benefit one third of the world's people. Mycobacterium tuberculosis (Mtb) is a causative agent of tuberculosis. Using conditional gene silencing technology, the researchers used to determine the genes necessary for Mtb infection in vivo, such as proliferation and virulence-related genes. Thus, the prcBA gene, which encodes a mycobacterial proteasome, was found to be an unknown essential proteasome in a murine chronic infection test. In mice with interferon-gamma deficiency, proteasome defects also affect Mtb, suggesting that the function of the proteasome is not only involved in the immune response. 20% of the Mtb gene is required in vitro, in vivo or both. Thus, by conditional gene silencing, it is easy to identify therapeutic targets for more than 800 anti-binding drugs, while increasing our understanding of host-pathogen interactions. ——Midi Medical Network

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