Type 1 Diabetes (T1D) is an autoimmune disease in which islet cells that produce insulin in patients are mistakenly destroyed by their own immune system. The current treatment for T1D is: daily injection or infusion of exogenous insulin to control blood glucose (BG) levels, but this method requires continuous patient attention and strict compliance. This method does not cure T1D or prevent many serious complications associated with diabetes, such as blindness, high blood pressure, kidney disease and vasculitis. Islet transplantation provides a potential replacement therapy for T1D and restores normal blood sugar. However, in order to avoid immune rejection caused by transplantation of islets, it is necessary to take an immunosuppressive drug for a long time to suppress, and at the same time, it also brings about side effects of an immunosuppressive drug. In the United States, more than 1 million Americans with type 1 diabetes inject insulin daily to control blood glucose (BG) levels. A research team from Cornell University has recently developed a revolutionary device that avoids the immunological rejection of islet transplantation and the side effects of long-term use of immunosuppressive drugs. In order to avoid the type 1 diabetes, insulin-producing pancreatic cell mass (islets) is destroyed by the body's immune system. Stem cell-derived islet cell transplantation is an alternative to insulin therapy, but this method requires long-term administration of immunosuppressive drugs. An in-depth study is to wrap the cells in a tiny capsule of a few hundred microns in diameter. However, these capsules are not easily removed from the body because they are not connected to each other and the number is thousands. A team led by Ma Minglin, an assistant professor of biology and environmental engineering at Cornell University, designed an ingenious method of implanting hundreds of thousands of islet cells into patients. These islet cells are protected by a thin layer of alginate gel coating, and the alginate gel enveloping the cells adheres to a polymer line that can be easily removed or replaced when the polymer line fails. . The graft should be easily removed, as long-term placement of the graft may induce tumor formation. "When the grafts don't work, we need to take them out," Ma Minglin said. "Moreover, people don't want to put things into the body and can't get them out, and we can easily remove them from the human body." Ma Minglin and his team said they were inspired by the water droplets that condensed on the spider web. Previously we tried to connect capsules containing islet cells with a thin wire. Later, after our exploration, we realized that it would be better to evenly place the alginate gel layer around a wire. Such nanoporous polymeric filaments can release calcium ions to promote consistency of in situ crosslinking and strong adhesion to alginate gels. In a short-term (1 month) study, a smooth alginate gel provided immunoprotection to the islets of C57BL/6 mice. Centrally augmented alginate gels in nanoporous polymeric filaments have better mechanical properties than smooth alginate fiber strands due to stringent requirements for handling and removal. Ma Minglin and his team further demonstrated the scalability and recyclability of this nanoporous polymeric yarn on dogs. This thread, called TRAFFIC (Thread-Reinforced Alginate Fiber For Islets enCapsulation), is inspired by spider webs, but is evenly covered by a layer of alginate gel. The whole thread, so this thread is better than the spider silk. There are no gaps between the capsules on the entire thread. If the silk thread has a gap like the water droplets on the spider silk, the influence on the scar tissue and the like will be great. This approximately 6 foot (about 182.88 cm) alginate gel smear can be implanted into the patient's abdominal cavity with minimally invasive laparoscopic surgery. TRAFFIC has been patented with the help of Danish pharmaceutical giant Novo Nordisk, which developed insulin for injection more than 80 years ago. Ball Valve,Sanitary Stainless Steel,Stainless Steel Tc Ball Valve,Sanitary Three Pieces Ball Valve Wenzhou Gaoya Light Industry Machinery Co.,ltd. , https://www.hongyafitting.com
