The development and differentiation of adipocytes play an important role in the etiology and pathogenesis of obesity. Although a number of studies have been conducted on fat precursor cells, our understanding of their intrinsic origin and characteristics is incomplete. Recently, scientists have used high-resolution single-cell transcriptomics technology to “light up†different types of stromal cells in adipose tissue, or to help improve our ability to control obesity and insulin sensitivity, and thus treat types including type 2 Metabolic diseases such as diabetes. The study was published in the journal Nature on June 20th titled "A stromal cell population that inhibits adipogenesis in mammalian fat depots." Scientists from the Ecole Polytechnique Federale de Lausanne (EPFL) and the Eidgenossische Technische Hochschule Zurich (ETHZ) in Zurich stated that “Using the resolving power of the single-cell transcriptome in a mouse model, we can Different subsets of adipose stem cells and precursor cells were found in subcutaneous adipose tissue matrices." The single-cell transcriptome can simultaneously draw "snapshots" of the gene expression of thousands of individual cells. Since cells in the same subpopulation have similar gene expression profiles, scientists can group cells based on their molecular similarities. Using this method, scientists first discovered several subpopulations of stromal cells in mouse adipose tissue. Subsequently, the team isolated these subpopulations and studied their cellular behavior. Surprisingly, they found that one subpopulation not only failed to differentiate into adipocytes but also actively inhibited the formation of fat from other fat precursor cells through a secretory mechanism. The researchers named the cells "adipogenesis-regulatory cells (Aregs)." Fat cells development may be suppressed by a newly identified subpopulation of regulatory cells in the stromal vascular fraction of fat tissue. These cells, called adipogenesis-regulatory cells, or Aregs, were identified in the fat tissue of mice. Was found in human fat tissue. (Left) Mature human fat cells grown in a Petri dish (green, lipid droplets). (Right) A section of mouse fat tissue showing, in the middle, a blood vessel (red circle) surrounded by Aregs (arrows). [Bart Deplancke/EPFL] What's more, scientists have also found similar fat-forming inhibitory cell populations in human adipose tissue. These findings provide a hope that Aregs can be used to regulate the plasticity of human adipose tissue. In the long term, this can improve our ability to control obesity and insulin sensitivity, thereby treating metabolic diseases including type 2 diabetes. "Our research shows that there are still many human cell types to be discovered," said Dr. Christian Wolfrum of ETHZ. "Some of these may have important implications for medicine, such as the Aregs we found in this study." "Controlling the formation of fat cells is not only important for improving metabolic health," added Dr. Bart Deplancke of EPFL. "It is also important for delaying aging because some tissues, like bone marrow and muscle, accumulate fat over time. It has a negative impact on its own function. Therefore, our findings have a wide range of biomedical implications and we can't wait to learn more about these interesting cells.†Responsibility: Floating Su References: 1) Fat Cell Suppressor Emerges from the Stromal Shadows Rabies vaccine is an active immunizing agent used to prevent infection caused by the rabies virus. The vaccine works by causing your body to produce its own protection (antibodies) against the rabies virus. Rabies Vaccine Injection,Rabies Antibody,Anti Rabies Dosage,Human Rabies Antibody Changchun Zhuoyi Biological Co., Ltd , https://www.zhuoyibiological.com
