Stroke (commonly referred to as stroke) has high morbidity, high mortality, high recurrence rate, and high morbidity. It has become the leading cause of disability in adults. Stroke causes a significant decrease in blood supply to a part of the brain, leading to the death of brain cells. Unlike most other tissues in the human body, brain tissue cannot be regenerated, and once it is dead, it is irreversibly absorbed and leaves an empty cavity that cannot be filled. Stroke patients will therefore suffer from cognitive impairment and dyskinesia. Over the years, researchers have been trying to find ways to promote the regeneration of the central nervous system, but this work is extremely challenging and a thorny problem for the medical community. A new study published recently in the UK's "Journal of Nature and Materials" said that a bioengineered gel can help brain tissue damaged by stroke.

Dr. Tatiana Segura, a researcher at the University of California, Los Angeles, led the team to develop this new gel. Once in the brain, it thickens and becomes a scaffold for the growth of new neurons and blood vessels. The gel contains stimulating blood vessel growth and anti-inflammatory compounds to prevent inflammation leading to scar formation and hinder brain tissue regeneration. In the experiment, the researchers used a mouse stroke model to inject the gel into the cavity resulting from the stroke. Later, they conducted a 16-week evaluation of the activity of the cavity and brain tissue regeneration. As a result, it was found that the gel was slowly absorbed by the mouse brain tissue, and the cavity was also covered with new blood vessels, axons, and nucleus. After gel treatment, the mice's exercise behavior was significantly improved.

Dr. Segura said that the new gel therapy has achieved a major breakthrough in the field of stroke rehabilitation, and will further explore its specific mechanisms and complete more test experiments in the future. (Wang Xingwang)


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