On August 3, 2018, researchers from the Southwest Medical Center recently discovered new ways to treat kidney cancer in two children. " Wilms tumor" is a common type of kidney cancer in children. In general, the treatment of the disease includes surgery, radiotherapy, and chemotherapy. Combination therapy has a significant effect on most patients, but it is also accompanied by significant side effects. Therefore, researchers hope to find treatments with fewer side effects. Previous studies have found that a common type of gene mutation in this type of tumor causes mutations in the miRNA synthesis process. Such miRNAs are capable of reducing the expression levels of specific proteins. However, the authors are not aware of the role of this miRNA in tumorigenesis. In a later study, the researchers found a relationship between miRNA and IGF2, a link that affects tumor development and progression. Later, the authors found that mutations in miRNAs led to an increase in the expression of PLAG1, which promoted the production of IGF2. In another study, the authors found that mutations in the DIS3L2 gene cause tumors. Previous studies have shown that DIS3L2 can regulate the level of miRNA, but the authors constructed this gene-deficient mouse and found that the defect of this gene does not affect the expression of miRNA, but it will increase the expression of IGF2. This discovery reveals a new mechanism of tumorigenesis. This finding indicates the importance of miRNAs for tumorigenesis and also provides new targets for the treatment of nephroblastoma. Information Source: Scientists identify new mechanisms underlying pediatric kidney cancer Original source: Kenneth S. Chen, Emily K. Stroup, Albert Budhipramono, Dinesh Rakheja, Diana Nichols-Vinueza, Lin Xu, Sarai H. Stuart, Abhay A. Shukla, Claudette Fraire, Joshua T. Mendell, James F. Amatruda. Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1. Genes & Development, 2018; 32 (15-16): 996 DOI: 10.1101/gad.313783.118 Manual Massage Foot Spa Massager A manual massage Foot Spa Massager is a device designed to provide a relaxing and therapeutic foot massage. It is a manually operated handheld device, which means it does not require electricity or batteries to operate. The massager is made up of several parts, including the handle, rollers, and knobs.
Overall, the Manual Massage Foot Spa Massager is a great option for those who are looking for an easy and effective way to relax and soothe their feet. It's affordable, easy to use, and can provide a range of health benefits, including improving circulation, reducing stress, and relieving foot pain and discomfort.
Manual Massage Foot Spa Massager,Portable Pedicure Tub,Bath Foot Massager,Foot Bath Machine Huaian Mimir Electric Appliance Co., LTD , https://www.mmfootbath.com
To use the manual massage foot spa massager, you simply place your foot on a flat surface and apply the massager to the soles of your feet. The rollers and nodules stimulate the nerves and muscles in the foot, providing a deep tissue massage that helps relieve tension and pain.
The massager is small and lightweight, so you can easily take it with you wherever you go. It's also easy to clean, just wipe with a damp cloth after each use.