Quick Details of GSK6853:
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Product Name
GSK6853
Synonyms
N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-benzamide
CAS No.
1910124-24-1
Molecular Formula
C22H27N5O3
Molecular Weight
409.5
SMILES:
C[C@H](CNCC1)N1C2=C(NC(C3=CC=CC=C3OC)=O)C=C4C(N(C)C(N4C)=O)=C2
Solubility
Soluble in DMSO
Target
Chromatin/Epigenetics
Signal path
Bromodoma
Appearance
White Powder
Purity
99%
Quality Standard
Enterprise standard
Storage Conditions
Store at -20°C
Packing
10g/foil bag;25kg/drum
Shipment
EMS;DHL;FedEx;TNT;UPS
Delivery Time
4-7 Working Days
Payment terms
T/T;Western Union;Money Gram;Bitcoin
General advice
For obtaining a higher solubility , please warm the tube at 37°C
and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Transportation conditions
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Usage
Cancer treatment
GSK6853 Descriptions:
GSK6853 is a BRPF1 inhibitor.
The BRPF (Bromodomain and PHD Fingercontaining) protein family are key scaffolding proteins
for assembly of MYST histone acetyltransferase complexes.
In vitro: In previous study, GSK6853 was tested in the BROMOscan panel of bromodomain
binding assays and the results showed that consistent with the previous findings, it showed
excellent BRPF1 potency (pKd 9.5) and greater than 1600-fold selectivity over all other
bromodomains tested. In addition, screening GSK6853 against a panel of 48 unrelated assays
revealed only off-target activities that were relatively weak compared to its high BRPF1 potency.
In vivo: To assess the suitability of GSK6853 for in vivo studies, its DMPK characteristics were
studied in male CD1 mice by i.v., po, and i.p. administration. The results indicated that the i.p.
route of administration would be suitable for dosing this molecule in further PK/PD models.
Moreover, in order to be able to compare biochemical potency measurements to free blood
concentrations, the fraction unbound in the CD1 mouse was also tested with a resulting value of
7.9%.
Our order process:
Step 1
Please tell me in what products you are interested including CAS number, quantities, and the destination country.
Step 2
You confirm all details and offer us purchase order.
Step 3
We offer the quotation of products and suitable shipping method for reference.
Step 4
You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc.
Step 5
We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h
Step 6
We offer after-sales service after you receive products.
Our competitive advantages:
Rich experience
Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Wide range of export
Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
High customs pass guaranteed
Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
Fast leading time
Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery
Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc
Â
99% Purity Anti-tumor Raw Powder GSK6853 CAS: 1910124-24-1
Quick Details of GSK6853:
Â
Product Name
GSK6853
Synonyms
N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-benzamide
CAS No.
1910124-24-1
Molecular Formula
C22H27N5O3
Molecular Weight
409.5
SMILES:
C[C@H](CNCC1)N1C2=C(NC(C3=CC=CC=C3OC)=O)C=C4C(N(C)C(N4C)=O)=C2
Solubility
Soluble in DMSO
Target
Chromatin/Epigenetics
Signal path
Bromodoma
Appearance
White Powder
Purity
99%
Quality Standard
Enterprise standard
Storage Conditions
Store at -20°C
Packing
10g/foil bag;25kg/drum
Shipment
EMS;DHL;FedEx;TNT;UPS
Delivery Time
4-7 Working Days
Payment terms
T/T;Western Union;Money Gram;Bitcoin
General advice
For obtaining a higher solubility , please warm the tube at 37°C
and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Transportation conditions
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Usage
Cancer treatment
GSK6853 Descriptions:
GSK6853 is a BRPF1 inhibitor.
The BRPF (Bromodomain and PHD Fingercontaining) protein family are key scaffolding proteins
for assembly of MYST histone acetyltransferase complexes.
In vitro: In previous study, GSK6853 was tested in the BROMOscan panel of bromodomain
binding assays and the results showed that consistent with the previous findings, it showed
excellent BRPF1 potency (pKd 9.5) and greater than 1600-fold selectivity over all other
bromodomains tested. In addition, screening GSK6853 against a panel of 48 unrelated assays
revealed only off-target activities that were relatively weak compared to its high BRPF1 potency.
In vivo: To assess the suitability of GSK6853 for in vivo studies, its DMPK characteristics were
studied in male CD1 mice by i.v., po, and i.p. administration. The results indicated that the i.p.
route of administration would be suitable for dosing this molecule in further PK/PD models.
Moreover, in order to be able to compare biochemical potency measurements to free blood
concentrations, the fraction unbound in the CD1 mouse was also tested with a resulting value of
7.9%.
Our order process:
Step 1
Please tell me in what products you are interested including CAS number, quantities, and the destination country.
Step 2
You confirm all details and offer us purchase order.
Step 3
We offer the quotation of products and suitable shipping method for reference.
Step 4
You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc.
Step 5
We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h
Step 6
We offer after-sales service after you receive products.
Our competitive advantages:
Rich experience
Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Wide range of export
Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
High customs pass guaranteed
Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
Fast leading time
Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery
Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc
Â
Model NO.: CAS: 1910124-24-1
Purity: 99%
Storage Conditions: Store at -20°c
Usage: Cancer Treatment
Delivery Time: 4-7 Working Days
Trademark: NJBN
Transport Package: 10g/Foil Bag; 25kg/Drum
Specification: 10g/foil bag; 25kg/drum
Origin: China
HS Code: 2901220000
Model NO.: CAS: 1910124-24-1
Purity: 99%
Storage Conditions: Store at -20°c
Usage: Cancer Treatment
Delivery Time: 4-7 Working Days
Trademark: NJBN
Transport Package: 10g/Foil Bag; 25kg/Drum
Specification: 10g/foil bag; 25kg/drum
Origin: China
HS Code: 2901220000
99% Purity Anti-tumor Raw Powder GSK6853 CAS: 1910124-24-1