Release date: 2016-08-12 Yesterday, Nature published an article in which researchers at the University of Houston discovered a natural fruit extract that dissolves calcium oxalate crystals, an important component of kidney stones, and then excretes them along with urine. This is the only and most significant advancement in kidney stone research in the past 30 years. If this technology becomes available, patients with stones around the world can be far away from the pain. Kidney stones are diseases that everyone is familiar with, but you may not know that this disease is plaguing 12% of men and 7% of women worldwide. This ratio is far beyond the expectation of singularity cakes, and it is reported that this disease The numbers are still rising. Traditional treatment of kidney stones, usually more than the use of extracorporeal ultrasonic lithotripsy, this method is non-invasive, fast, but can not eradicate stones, patients may face repeated attacks. So now there are many patients who choose percutaneous nephrolithotomy, a minimally invasive procedure, a lumbar incision, a passageway to the kidney, an insertion into the nephroscope, and the use of ultrasound or laser equipment to break the kidney stones. exclude. Although the wound is smaller, due to interventional surgery, there is still a risk of damage to surrounding tissues and organs and intraoperative bleeding. Comrade BioTalker, the senior editor of the editorial department, told Benqi to order. In his hometown, there is an old saying called "I would rather have children, no kidney stones." It can be seen how difficult it is for patients with kidney stones! So if there is a treatment that does not require surgery or pain, how good it is! Then we return to the "natural extract" discovered by the University of Houston researchers at the beginning, which is hydroxycitrate (HCA), HCA is a derivative of citric acid (CA), and its chemical structure is similar to CA. It is widely found in tropical rainforest plants such as Garcinia Cambogia and Roselle. Clinically, doctors will also recommend CA (in the form of potassium citrate) to treat kidney stones, which can slow the formation of calcium oxalate crystals, but it also has some side effects of nausea or vomiting or hyperkalemia. Some patients can hardly endure these side effects. Leading the study, Jeffery Rimer, an associate professor at the University of Houston, said that in the past studies of crystal formation inhibitors, the most effective inhibitors only hindered the formation of crystals, and this was the first time they discovered HCA. At a specific concentration, calcium oxalate crystals can be dissolved. (The picture on the right is Garcinia Cambogia) This amazing discovery was first discovered by the team's assistant researcher Jihae Chung, who discovered the process of calcium oxalate crystals getting smaller in HCA solution under atomic force microscopy, but Professor Rimer thought it was just an anomaly. But through experimental verification, he found that Chung's conclusion is correct. According to the experimental results, when the concentration of HCA is <0.08μg/ml, the synthesis speed of crystals is slower than that of the control group; when the concentration is 0.08-0.15μg/ml, the crystals can be seen to be dissolved layer by layer; When it is raised to 0.15 μg/ml or more, a part of the crystal disappears. For a clearer comparison, the researchers used a supersaturated HCA solution and an unsaturated HCA solution for comparative experiments. Under the microscope, the degree of corrosion of the crystals was small, but the corrosion rate of the supersaturated solution was significantly faster than that of the unsaturated solution. After discovering the dissolution of HCA on calcium oxalate crystals, Professor Rimer conducted another comparative experiment comparing the effects of HCA and CA on the inhibition of crystallization. The researchers controlled the simulated urine at a pH of 8.0 and found that the concentration of the two solutions was gradually increased. The inhibitory effect of HCA on calcium oxalate crystals was 62%, while CA was only 39%. Jeffery Rimer Jihae Chung The researchers simulated the formation of kidney stones, and the solution was cultured for 3 days at 60 ° C. a. Crystallization without inhibitors b. Inhibition of CA solution at a concentration of 20 μg/ml Through a high-precision calculation method, the researchers found that the therapeutic effect of HCA is to form a relatively strong bond with calcium oxalate crystals, inducing crystals to "relax the hands of calcium ions and oxalates" and make them free. The purpose of dissolving calcium oxalate crystals is achieved. HCA is neither a human body nor a compound in the human body during treatment, so after completing its mission, it must be discharged from the body to ensure safety. Of course, the researchers also thought that they had experimented with 7 volunteers and found that HCA can be excreted with urine, which is a perfect conclusion for this preliminary study. Although the experiment is smooth, it needs to be considered as a drug in the later stage. The safety and dosage of long-term use must be considered. Of course, there are clinical trials that cannot be omitted. This is of course the team of Professor Rimer. One direction of hard work. This research is necessary. If there is no good drug to treat kidney stones, if it succeeds, it will be a milestone in the history of treatment. Source: Singularity Network Safety shoes
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