A new mechanism for antibacterial natural immune response is revealed October 22, 2018 Source: Health News Network The international authoritative academic journal "Cell" magazine recently published the results of new research in the field of natural immunity and inflammation by the team of Chinese Academy of Engineering and the president of Nankai University. The study found that innate immune cell migration is critical for the assembly and expression of interferon receptors on the cell membrane surface, which in turn allows immune cells to effectively perceive interferon and activate natural immune functions to eliminate intracellular bacterial infections. This discovery reveals a new mechanism of regulation of the innate immune response from the perspective of cytokine receptors, and also provides a new idea for the prevention and treatment of intracellular bacterial infections of Mycobacterium tuberculosis. Innate immune cells such as macrophages are capable of clearing intracellularly infected bacteria under the activation of type II interferons. After perceptual pathogen invasion, macrophages and other blood vessels migrate out of the blood and migrate to the infected site, which plays a key role in the function of its natural immune function. However, how the cell migration affects its anti-intracellular natural immune function is not yet clear. Under the support of the Chinese Academy of Medical Sciences Medical and Health Innovation Project and the National Natural Science Foundation, Dr. Cao Xuetao and Dr. Xu Xiaoqing from the Institute of Immunotherapy of the Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences found that macrophages adhered to the surface of vascular epithelial cells during migration. Molecular E-selectin interaction activates macrophage tyrosine kinase molecules and then site-selective phosphorylation of type II interferon receptor subunit 2 in the cell, resulting in phosphorylated receptor subunit 2 Binding to the transporter facilitates its transport from the Golgi to the cell membrane; it eventually binds to the additional interferon receptor subunit 1 on the cell membrane and assembles into a functional interferon receptor. This series of assembly enables macrophages to respond to external interferon and exert their antibacterial effects. This study has important implications for elucidating the dynamic process of cell membrane receptor expression, particularly the role of protein modification in the dynamic expression of receptors on the cell membrane surface; for other cytokine receptors and immune cell inhibition and activation Physical research is also instructive. From the new perspective of cytokine receptor membrane expression regulation to study whether natural immune cells can effectively respond and function, it provides potential targets and ideas for immunotherapy of chronic infectious diseases, inflammatory diseases and tumors.
A contour measuring instrument is a precision equipment used to measure the shape of various mechanical parts' lines and cross-sectional contours. The instrument workbench adopts high-precision horizontal air floating track and rolling vertical track, with high movement accuracy, good stability, and long service life; High measurement efficiency, simple operation, suitable for use in workshop inspection stations or measurement rooms.
The instrument workbench adopts high-precision horizontal air floating track and rolling vertical track, with high movement accuracy, good stability, and long service life; High measurement efficiency, convenient card installation, simple operation, suitable for use in workshop inspection stations or measurement rooms. This instrument can further develop software according to the needs of users, meet their measurement shape requirements more widely, and is equipped with various equipment components for users to choose and use according to their own requirements.
A contour measuring instrument is a precision equipment used to measure the shape of various mechanical parts' lines and cross-sectional contours. In the bearing industry, it is possible to measure the contour shapes of various rolling elements and raceways, such as protrusion, contact angle, surface curvature radius, and reference part angle. In the mechanical industry, it is possible to measure the straightness, line profile, parallelism, inclination, and angle of various parts. Especially suitable for measuring the appearance of pistons in automobiles, tractors, and motorcycles. The production instruments of this research run enterprise are controlled by microcomputers, which automatically achieve measurement cycles, eliminate installation errors, directly display the shape and parameters of the measured parts, and can print graphics and data for product quality testing and process analysis.
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