Release date: 2017-10-12 According to MedicalNewsToday reported on October 1st, Beijing time, researchers at the Houston Methodist Institute in the United States, using new technology, can reverse the aging markers in children with premature aging. The project's lead researcher, John Cooke, studied cells in children with premature aging in order to gain a deeper understanding of the aging process. They believe that new research can lead to the treatment of other diseases related to aging. Premature aging in children is a rare disease caused by mutations in the LMNA gene, which is found in fewer than 250 children worldwide. Children with premature aging also have common symptoms in the elderly, including heart and circulation problems, joint stiffness, and hip dislocation. Most patients die of heart disease or stroke, and almost no one can live sixteen or seven years old. Cook said, "We hope to extend their survival and improve the quality of life, so we have studied their cells and hope to improve cell function." Often, the study of diseases caused by defective genes is aimed at correcting genetic defects and altering related proteins. But Cook and his colleagues decided to study the problem from different angles: they focused on telomeres. Telomeres are DNA and protein structures located at both ends of a chromosome that protect genes. Their function is very similar to the plastic seals at the ends of the lace to prevent damage to the gene. As you age, the telomeres become shorter: each time the cells divide, the telomeres lose a portion. When the telomere is shortened to a certain level, the cell goes to the end of its life and no longer divides, or undergoes a process of cell death called apoptosis. Shortening of telomeres is thought to be associated with high morbidity and shortened lifespan. In this sense, telomere length is a bit like a "biological clock" that can be used to predict the lifespan of a cell or organism. The team noted that telomeres in children with premature aging are much shorter. They decided to try to improve the function and division of these cells by extending telomeres. The research team used a new technology called RNA therapy - injecting small molecules into cells and changing their gene expression. They obtained cells from children with premature aging that produce telomerase, a protein that extends telomeres. After several days of treatment, the cells showed many positive changes. Cook said that they were surprised by the fact that a treatment can produce such a good effect. "The great effect on cell division ability is what we did not expect. The cells can function and divide normally. We extend the life of the cells so that They work better." The research team compared the effects of RNA therapy with traditional therapies and found some dramatic changes. Cook said that as a doctor, many of the diseases he encountered were caused by aging, such as cardiovascular disease. Cook said that because their research suggests that RNA therapy can reverse the process of telomere shortening in children with premature aging, it may "reverse a number of problems associated with aging." Cook and colleagues believe that their research will be used clinically in the next few years. "Our next step will be to start using this therapy for clinical applications." Scientists can reverse the process of telomere shortening Source: Phoenix Technology LED Vanity Light,led tubes mirror bathroom light,fluorescent tube bathroom mirror light Ningbo Wellway Optoelectronic Technology Co.,Ltd , https://www.wellwayopto.com