The reporter learned from Xi'an Jiaotong University on the 15th that the joint research team of Professor Zhang Ching, Associate Professor Chang Zhengshi and Associate Professor Shi Xingmin from the School of Electrical Engineering of the school combined the low temperature plasma with the clinical antitumor chemotherapy drug Tegafur, which significantly reduced cell DNA replication. The ability to obtain a good tumor cell proliferation inhibition effect provides a new idea for low temperature plasma assisted tumor therapy.
Pancreatic tumor is a malignant tumor of the digestive tract with high malignancy and difficulty in diagnosis and treatment. Its morbidity and mortality have increased significantly in recent years. The 5-year survival rate is <1%, which is one of the worst prognosis. The early diagnosis rate of pancreatic tumor is not high, the operative mortality rate is high, and the cure rate is very low, known as the "king of the tumor." At present, the treatment is mainly based on surgery, combined with radiotherapy and chemotherapy. However, pancreatic tumors are less sensitive to radiotherapy. Chemotherapy is mainly used to reduce the chance of recurrence after surgery, and the side effects of both are large, killing tumor cells and killing normal cells.
Xi'an Jiaotong University Zhang Champion led the research team to long-term commitment to low-temperature plasma characteristics and applied research in biomedical fields, including microbial inactivation, tumor cell inhibition, wound healing, food sterilization and preservation. They combined low-temperature plasma with clinical anti-tumor chemotherapy drug tegafur, and synergistic treatment of human pancreatic tumor cells cultured in vitro, which greatly reduced the dose of tegafur. Plasma synergized with tegafur significantly reduced cell DNA. The ability to replicate has a significant inhibitory effect on tumor cell proliferation. This achievement was recently published in the internationally renowned journal "Plasma Process and Polymer" of the John Wiley Academic Publishing Group in the United States, and was selected as the "Inhibition Effect of Non-thermal Plasma Synergistic Tegafur on the Enhancement of Pancreatic Tumor Cells". Journal cover article. (Reporter Shi Junbin)
Source: Technology Daily
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