The Department of Disease Mechanism Genetics and Evolutionary Medicine of the Kunming Institute of Zoology, Chinese Academy of Sciences recently joined local medical institutions and experts such as the First Affiliated Hospital of Kunming Medical University to make new progress in the study of genetic susceptibility to leprosy. The researchers analyzed two important genes TFAM and POLG related to mitochondrial replication, and found that rs1049432 and rs3176238 locus variation in these two genes affected leprosy genetic susceptibility and leukemia in leprosy patients in Yuxi, Yunnan. Leprosy is significantly related. After further sequencing the leprosy patients in Wenshan, they failed to find leprosy-susceptible protein variants in the coding regions of these two genes. The analysis showed that the above gene locus variation can affect gene expression in nerve tissue and skin tissue, and there is a significant difference in the expression of leprosy lesions and normal skin tissues. Studies suggest that TFAM and POLG are susceptibility genes for leprosy, and their mechanism may be achieved by regulating gene expression. This study provides new evidence for host genetic background and mitochondrial metabolism affecting leprosy susceptibility and provides new insights into understanding the pathways and shared genetic basis of leprosy and neurodegenerative diseases. Leprosy is caused by infection with M. leprae. Pathogens mainly invade the skin, mucous membranes and peripheral nerves of patients, and can cause severe disability after infection. At present, there are still more than 200,000 new cases of leprosy every year worldwide. The findings have recently been published in the International Journal of Dermatology, Dermatology, and the British Journal of Dermatology. (Technology Daily) Cosmetics are compound mixtures made from various raw materials after reasonable blending and processing. There are many types of cosmetics raw materials with different properties. According to the raw material properties and uses of cosmetics, it can be roughly divided into two categories: base raw materials and auxiliary raw materials. The former is a main raw material of cosmetics, which occupies a large proportion in cosmetic formulations, and is the main functional substance in cosmetics. The latter is responsible for shaping, stabilizing or imparting color, fragrance and other characteristics to cosmetics. These substances are not used in large amounts in cosmetic formulations, but are extremely important. Cosmetics are chemical mixtures made of natural, synthetic or extracted substances with different functions as raw materials and processed through production processes such as heating, stirring and emulsification. Collagen peptide, Arbutin, Coenzyme Q10, GSH, Cosmetic Raw Materials, lipoic acid Xi'an Gawen Biotechnology Co., Ltd , https://www.ahualynbio.com