Research found potential drugs for brain repair April 05, 2017 Source: Bio Valley 2017 Brain Science and Brain Intelligence Symposium Throughout adulthood, neural stem cells from the subventricular zone develop into new nerves and supporting cells, oligodendrocytes. Transcriptional changes associated with various cell development in newborn mice are categorized in public databases, and similar transcriptional changes caused by various chemical substances approved for clinical use are also classified. In this new study, the authors used these databases to find that transcriptional changes caused by cell differentiation and drug treatment overlap, suggesting that these drugs may be potential drugs to reverse neurodegenerative diseases. To this end, they studied the differences in signaling pathways in various regions of the subventricular zone, and found that there are several important differences between the neural-specific microdomains and the oligodendrocyte microdomain signaling pathways, and they use these findings. Similar gene expression level changes were screened in the small molecule drug database. As a result, they found a series of small molecule drugs with similar transcriptional signals. One of them, called LY-294002, specifically promotes the production of normal oligodendrocytes by neonatal mouse neural stem cells. In adult mice, different molecules (AR-A014418 and CHIR99021) can eliminate the neurogenic activity and the disappearance of cell diversity in the subventricular zone of adults. The latter was found to have a strong ability to promote oligodendrocyte regeneration and a slight increase in the number of neurons in the perinatal hypoxic brain injury model. These results can be used in several ways: 1) Because the small molecule drug database points out important cellular pathways, they provide new insights into the mechanisms of neural development and repair that can be used to explore new therapeutic strategies. 2) They have discovered several new drugs that have been approved for clinical use and can now explore the potential role of these drugs in repairing brain damage. 3) They provide a conceptual new way to discover drugs that directly affect nerve regeneration and may be used to treat brain diseases. "Controlling the fate of neural stem cells is a key therapeutic strategy for regenerative medicine," Azim and colleagues said. "The strategy shown in our study allows us to quickly identify multiple drug candidates and incorporate them into drug development lines for their treatment. The potential can be further assessed." Clinic Nitrile Gloves,Nitrile Gloves Small,Medical Gloves Unsterilized,Nitrile Gloves Powder Free Latex Free Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshihealths.com
Kasum Azim of the University of Zurich and colleagues from the University of Lyon and the University of Portsmouth have discovered a new drug that activates mouse brain stem cells to develop into mature brain cells. This study was recently published in PLOS BIOLOGY. This discovery may open up new ways to develop new drugs for the treatment of degenerative brain diseases.