American researchers 3D printed a transparent skull implanted in the mouse's brain to observe the neural activity on the whole brain surface of the mouse in real time. This will help people understand the pathogenesis of human brain diseases such as concussion, Alzheimer's disease and Parkinson's disease. The study, published in the recent British journal Nature, shows the implantable device called "See-Shell." It can help researchers master the global dynamics of the mouse brain. The latest brain science research believes that some brain regions will affect other brain regions at the same time. Suhasa Kodandarama, co-author of the paper and assistant professor at the University of Minnesota, said that this technique allows us to activate a specific brain region with unprecedented levels of control and precision to observe most of the cerebral cortex. activity. The researchers first scanned the mouse skull, 3D printed a transparent artificial skull with the same contour as the original skull, and surgically replaced the mouse skull. Studies have shown that the body of the mouse does not reject the implant, so researchers can study the brains of the same mouse for several months. In one experiment, the researchers looked at how a minor concussion in one brain region of a mouse would affect other brain regions. The video shows that the brightness of the brain brainwave signal changes with the fluctuation of nerve activity, but the researchers have not yet figured out the relationship between the global coordination of brain regions and behavior. There are many similarities between the rat brain and the human brain. Researchers say that the use of implantable transparent 3D printed skulls to study the brain of mice can help people better understand the mechanisms of brain degenerative diseases such as Alzheimer's disease. (Source: Xinhua News Agency Zhou Zhou) Related paper information: https://doi.org/10.1038/s41467-019-09488-0 Source: Xinhua News Agency
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:2019-04-16