Tet enzyme "can only be closed"? My scientists have proved that the "precision closed loop" of immune regulation January 26, 2018 Source: Science and Technology Daily On the 24th, Nature published an online paper by the Academician Cao Xuetao, director of the State Key Laboratory of Medical Immunology, and reported that the DNA-modifying enzyme Tet2 promotes the body's new mechanism of increasing the number and function of natural immune cells. This mechanism regulates RNA modification. Complete its function. The natural immune and inflammatory response in the human body requires the “double insurance†of the switch. It is necessary to “get it rightâ€, moderately promote the early occurrence of immune inflammation to resist infection, and “return the standard†to avoid damage caused by excessive inflammation. As early as 2 years ago, the team of Cao Xuetao published a paper on Nature to reveal the mechanism by which the Tet2 molecule "closes" the immune response, and the Tet2 enzyme does not have the "switching in one" regulation function. This study demonstrates the ability of the Tet2 molecule to "turn on" the innate immune response and to create a "precise closed loop" for the immune regulation mechanism. The researchers studied the role of RNA modification in innate immunity and inflammation from the perspective of the apparent transcriptome. It was found that the DNA methylolase Tet2 acts as an RNA-binding protein at the level of immune mRNA (messenger RNA) and promotes infection. In the state, the number of natural immune cells in the peripheral blood of the machine is increased, which is beneficial to the removal of pathogens. To reveal its molecular mechanism, the team discovered Tet2 using UV-crosslinking immunoprecipitation combined with high-throughput sequencing (CLIP-seq) and RNA-related sequencing techniques such as single nucleotide resolution of full transcriptome RNA methylation sequencing. It can directly bind to the 3' untranslated region of the mRNA of the negative regulatory molecule Socs3, and the 3' untranslated region of eukaryotic mRNA is an important part of interaction with various cellular transactivators. The combination of Tet2 and this important department inhibits the methylation of RNA cytosine in this region, promotes the degradation of Socs3 mRNA, inhibits the negative regulation, and achieves the effect of “negative negative positiveâ€, which in turn promotes the body's natural immunity in the early stage of infection. The occurrence of cells and their function. The study also showed that cytosine methylation at the RNA level has a new function in mammals, that is, regulation of immune signaling pathways, which provides new ideas and potential drug development targets for effective prevention and treatment of infectious diseases and control of inflammatory diseases. (Reporter Zhang Jiaxing) Zhoushan City Shuangying Aquatic Products Co., Ltd.  , https://www.shuangying-aquatic.com