Genomics research reveals the health protection mechanism of Shouxing November 9th, 2018 Source: Science and Technology Daily Author: Zhao Hanbin Centenarians can usually delay or even avoid some major senile diseases. The researchers recently found that autophagy-lysosomal signaling pathway gene expression up-regulation is the most significant signal of Shouxing, and is an important health protection mechanism for longevity. The Kunming Institute of Zoology, Kunming Institute of Zoology, Chinese Academy of Sciences, Zhou Jumin and the team of Professor Cai Wangwei of Hainan Medical College have recently obtained and analyzed the peripheral blood leukocyte transcriptome data of 171 samples from Hainan Changshou family. Based on a series of bio-information analysis and detection, the team found that autophagy-lysosomal signaling pathway gene expression up-regulation is the most significant signal for centenarians, and this signal also exists in the descendants of Shouxing. In view of the autophagy involved in lysosomes, it can selectively degrade damaged organelles and proteins in cells, and release free small molecules for cell reuse, in order to further confirm that autophagy-lysosomal signaling pathway function enhances aging, To promote longevity, the research team selected four autophagy-lysosomal signaling pathway genes and performed expression experiments in human embryonic lung fibroblasts IMR-90. It was found that high expression of these four genes can enhance autophagy. It also significantly delayed cell senescence; they also used the relevant system to conduct gene overexpression studies in Drosophila and found that it did significantly extend the lifespan of Drosophila. Therefore, the team based on omics analysis and functional experiments such as cells and fruit flies suggest that this signaling pathway is enhanced and may contribute to the longevity of human health. The research was published in the international journal Genomics and was selected as the cover article for the 11th issue of the magazine. The research not only reveals the protection mechanism of human health and aging, but also provides a new perspective and new strategy for delaying aging and improving the health of the elderly. Tourmaline heating mat,Jade mattress,Natural jade and tourmaline mat,Tourmaline infrared heat mat Guangzhou Fuerle Health Technology Co., Ltd , https://www.fuerlegroup.com