Release date: 2016-11-22 When we are attacked, we will counterattack, we will gather teams to attack the enemy, and we will continue to support and assist the injured comrades. This is a minimum attempt, but at the Gul Cancer Institute in the UK ( In the Cancer Research UK Gurdon Institute, this basic approach is probably not the most popular. Researcher Steve Jackson founded the institute 25 years ago, and now researchers have developed a new drug that can Use a counter-in-the-course approach to treating cancer by shutting down the mechanisms that repair the body's DNA and inhibiting DNA mutations. Researcher Jackson, like other scientists in the Gurdon Institute, is a scientist engaged in basic research. In other words, his research is to clarify the basic mechanisms of the body's work, but basic science often lacks "fashion" but lacks basic research. We also cannot develop more new drugs for disease treatment. The drug, Lyparza, is based on research by Jackson, who received FDA approval in 2014 and has now been widely used in more than 40 countries. In fact, the breakthrough moment of the researcher is the result of long-term observation, and Jackson also discovered an enzyme that can be activated by DNA, and this enzyme can actually be activated by DNA fragmentation, now in the laboratory. Most of the DNA used in the process is circular, but Jackson used long strips of DNA for related research. He said that if we use circular DNA for research, we may never see long strips of DNA. The effect of this special enzyme can be activated by DNA fragmentation, and the enzyme is also involved in the DNA repair process, which is the second DNA repair enzyme (PARP enzyme), which can help The development of the drug Olapani. DNA repair is critical to our survival, and today we have evolved an alternate mechanism to prevent PAPR enzyme inactivation, a mechanism of homologous recombination, in which case DNA can be extended under the same fragment, In some cancer cells, it is worth mentioning that in the cancer cells with BRCA1 and BRCA2 mutations, the above mechanisms are often inactivated, and the tumor cells of the individual carrying these genes often carry two copies of the "bad" gene. It can promote the inactivation of the homologous recombination process, but the healthy cells of the body carry the correct genes, so that they can exercise the correct function. The researchers point out that if we can block the PARP repair mechanism in these individual organisms, healthy cells may be able to restore function and survive, and tumor cells will die. One-third of patients with ovarian cancer are caused by mutations in the BRCA gene. Recent studies have shown that approximately the same proportion of patients with prostate cancer are directly related to BRCA mutations, and in one in ten breast cancer patients, If the drug Olapani can be approved, then the gas can improve the survival of many patients, but the drug is not perfect, it does not work for all BRCA patients and some drug-resistant patients, but can significantly prolong the patient Life expectancy. Jackson said that we all hope to cure cancer completely, and now PARP inhibitors can effectively treat some cancer patients, but all we do is turn cancer into a disease that can be controlled for a long time, and at different stages of the disease. Controlling; like many scientists at the Gurdon Institute, the researcher Piddini has done a lot of research on many simple organisms. In addition to researching humans, Jackson has also conducted research on yeast, and Piddini has supplemented the study of hard work. We didn't have the same ancestors millions of years ago, but we have many of the same basic processes in the body. Researcher Piddini has conducted in-depth research on the mechanisms of cell-to-cell competition, especially how cells communicate and how they make tissues select the strongest cells. Of course, this may be a special quality control, but studies have shown that cancer cells have It also self-disguise, making the cells look very strong enough to kill a variety of cells in the vicinity. Researchers believe that this may help them explain why cancer spreads rapidly in the body (cancer metastasis). Many current chemotherapy drugs promote apoptosis, which not only damages healthy cells, but also uses cancer cells. Apoptosis protects against the growth of healthy cells, which produces a seemingly abnormal behavior on the surface that blocks cell death. If we can inhibit apoptosis, we can let healthy cells survive, and if healthy cells survive, we can block the spread of cancer cells and promote tumor death. This is a huge study so far, and when it comes to PARP inhibitors, researchers have shown an optimistic attitude. Finally, Piddini said that in the later period we will develop more new methods to fight cancer through a number of joint research. Original search "A counterintuitive approach to fighting cancer" Source: Bio Valley Household Medical Equipment,Power Wheelchair For Disabled,Nursing Home Care Bed,Medical Equipments For Disabled Patient Haloxylon Ammodendron Medical Equipment Co., Ltd. , https://www.haloxylonhospital.com