Medicinal value Antimalarial effects: Artemisia annua - Chinese herbal medicine Artemisia annua - Chinese herbal medicine The neutral part of the extract of Artemisia annua L. and its dilute alcohol extract showed significant antimalarial effects against M. malaria, M. sinensis, and human malaria. In vivo experiments showed that artemisinin has a killing effect on the erythrocytic endometriosis of Plasmodium erythraea, but it is not effective on the erythrocyte exosomal stage and the pre-erythrocytic stage. Artemisinin has the effect of rapidly inhibiting the maturation of protozoa. The antimalarial effect of artemether emulsion is better than that of reducing artemisinin sodium succinate, which is an ideal dosage form for treating dangerous malaria. Artesunate 2.5, 5, 10, 15mg/kg, 2 times / day for 3 consecutive days, external skin spasm, treatment of monkey malaria have different degrees of efficacy. 5, 10mg/kg, 2 times / day, for 10 consecutive days, the skin can make monkeys malaria turns negative. Adding a suitable amount of atropine can increase the antimalarial effect. The ED50 and ED90 values ​​of decarbonylated artemisinin and carbodecaine artemisinin in mice were respectively 12.6 mg/kg and 25.8 mg/kg for Plasmodium berghei strain K173 strain. In vitro experiments showed that artemisinin can significantly inhibit the growth of Plasmodium falciparum asexual body and have a direct killing effect. The IC50s of artemisinin, artemether, and chloroquine against Plasmodium falciparum were 75.2, 29.4, and 43.2 nmol/L, respectively. Artemisinin sodium has inhibitory effects on 6 isolates of Plasmodium falciparum (including anti-chloroquine strains). [Antibacterial effect]: Artemisia annua water decoction has a strong antibacterial effect on Staphylococcus epidermidis, Catarrhythmic, Bacillus anthracis, diphtheria bacilli, and also has a certain inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa, dysentery bacilli, tuberculosis stalks. Artemisia annua L. volatile oil has antibacterial activity against all dermatophytes at a concentration of 0.25%. At a concentration of 1%, it has a bactericidal effect against all dermatophytes. Artemisinin has anti-influenza virus effects. Artemisinin sodium has a certain antibacterial effect on gold grapes, Shigella flexneri, Escherichia coli, Catascus, A and B paratyphoid strains. The sitosterol and stigmasterol in Artemisia annua also have antiviral effects. ã€Antiparasitic effect】: Artemisia annua (Figure 7) Artemisia annua (Figure 7) Artemisinin extracts, dilute alcohol extracts and artemisinin exhibited significant antimalarial effects on mouse malaria, monkey malaria and human malaria. In vitro culture suggests that artemisinin has a direct killing effect on Plasmodium. Electron microscopic observations showed that artemisinin mainly acted on the membrane phase structure of plasmodium in erythrocytic asexual cells, first acting on food color film, pellicle and mitochondrial membrane, followed by nuclear membrane and endoplasmic reticulum. In addition, it also affects the nuclear chromosomes. As a result of the change in the cell membrane, it blocks the early stages of malnutrition and causes the amino acid starvation of the malaria parasite, resulting in the formation of autophagic vacuoles. The autophagic vacuole is continuously excreted, causing a large loss of pulp and the collapse of internal structures. Artemisinin is highly effective against Plasmodium falciparum, Plasmodium falciparum and Plasmodium falciparum resistant to Plasmodium falciparum. It has the characteristics of high fever, rapid fever, and rapid protozoa turning time. It is particularly suitable for rescuing dangerous malaria, but the re-ignition rate is high. In addition, Artemisia annua has anti-schistosomes and Leptospira effects. ã€Antipyretic effect】: The Artemisia annua L. injection prepared by distillation has obvious antipyretic effects on rabbits exposed to 100, 100, and 300 mg of triple vaccine. Artemisia annua L. and honeysuckle group prescriptions, Qingyin injection prepared by distillation method, had a more pronounced fever-reducing effect on typhoid, paratyphoid A and B triple fever-inducing rabbits than single-articulated artesunate injection. Its cooling characteristics are rapid and lasting, which is superior to the control group of Bupleurum and Antongding injection. Honeysuckle and Artemisia annua have a synergistic antipyretic effect. [immune effect]: The immunological effects of artemisinin were observed using mouse footpad assays, lymphocyte transformation assays, rabbit-specific rosette assays, and hemolytic plaque assays. It was found that artemisinin has a significant inhibitory effect on humoral immunity. Cellular immunity has a promoting effect and may have immune regulation. Artemisinin and artemether promote the proliferation of splenic TS cells. Intramuscular injection of artemether also significantly inhibited T lymphocytes in Be, B, Tu, and Tr lymphocytes. It also significantly reduced serum IgG levels in normal mice and increased spleen weight. Reduce serum IgG levels in mice sensitized with chicken red blood cells. Intravenous injection of artemisinin 50-100mg/kg can significantly increase the phagocytosis rate (50.2-53.1%) and phagocytic index (1.58-1.91) of mouse peritoneal macrophages. Artemisinin can also increase lymphocyte transformation and promote cellular immunity. Artesunate can promote the proliferation of Ts cells, inhibit the production of TE cells, prevent the release of interleukins and various inflammatory mediators, and thus play an immunomodulatory role. [The role of the cardiovascular system]: Perfusion of rabbit hearts showed that artemisinin can slow down heart rate, inhibit myocardial contractility, and reduce coronary flow. Intravenous injection has the effect of lowering blood pressure, but it does not affect the pressor response of norepinephrine. It is believed that the main direct inhibition of the heart is changed. Intravenous injection of 20 mg/kg artemisinin can resist arrhythmia induced by aconitine in rabbits. [Other effects]: Artesunate can significantly shorten the sleep time of mice with pentobarbital. Artemisinin has obvious curative effect on experimental silicosis. Artemether has protective effects on mice. We are professional manufactuer of varieity Plant Extract, Animal Extract, Active Pharmaceutical Ingredients, Food additive, such as Hot Sales products: Alpha Lipoic Acid, Turkesterone Powder, Coenzyme Q10 , Rutin NF11, Butterfly Pea Flower Powder, Sheep Placenta Extract. Our products quality and service had been recognized by world wide customers. So, we can your reliable supplier. Beta-ecdysone Powder,Orlistat Powder,Coenzyme Q10,Rutin NF11,Butterfly Pea Flower Powder Xi'an Quanao Biotech Co., Ltd. , https://www.quanaobio.com