Release date: 2016-06-23 It's hard to believe that some cancers magically disappear, but it's sure to happen. More than a thousand case studies documented cancer patients who experienced a natural regression of the tumor. So why is this happening? Is it possible to use this to benefit cancer patients? Source: Bio Valley Our natural sweetener is extracting from natural plant. Like inulin powder, there are jerusalem artichoke and chicory sources. Monk fruit extract has sweetness of hundreds times than that of sugar. As natural food ingredient supplier, we also supply bulk sweetener like fructo-oligosaccharide, xylooligosaccharide, xylitol, sorbitol, Stachyose, D-Allose, erythritol, stevia extract powder which has very similar taste with sugar, we also accept blend customization of sweetener, please feel free to reach us for more if any interests! Natural Sweentener,Inulin Powder,Bulk Sweetener,Monk Fruit Extract YT(Xi'an) Biochem Co., Ltd. , https://www.ytherblifes.com
The earliest recorded cases of cancer regression were in the late 13th century. Osteosarcoma of the Roman Catholic saint Peregrine Laziosi spontaneously disappeared after a serious bacterial infection. At the end of the 19th century, American surgeon William Coley observed that induction of fever may lead to tumor regression. He developed a bacterial vaccine (known as the Cole vaccine) that can cause tumor shrinkage in many of his patients.
It is known that in the absence of any targeted therapy, the tumor will spontaneously disappear and usually occurs after infection (bacteria, viruses, fungi, even protozoa). Does this mean that simply activating the immune system can cause the tumor to subside?
Over the past 70 years, the natural regression of tumors has been reported in many types of cancer, especially melanoma (a type of skin cancer), renal cell carcinoma (a type of kidney cancer), neuroblastoma (neuroblastoma) and some types. Blood cancer. However, despite the history of these tumor regressions, we still don't know the mechanism that led to this phenomenon. In addition, many cases are probably not reported in research papers because they are difficult to quantify.
Not so simple
One possible cause of natural regression of the tumor is that the human body triggers an immune response against a specific antigen displayed on the surface of the tumor cell. Evidence supporting this view stems from the observation that there are excessive amounts of human immune cells inside some skin tumors (malignant melanoma).
In another case report of concern, a kidney cancer patient surgically removed some of his tumor, which caused the rest of his tumor to naturally resolve. The rationale for this phenomenon is that the local immune response after surgery is sufficient to prevent the remainder of the tumor from growing.
However, the tumor has a very large change in its genetic characteristics and behavior, which will lead to the continuous deterioration of some people, but it will also cause other people to naturally disappear. The same type of tumor (such as breast cancer) can be mutated in different ways. This can affect the rate of tumor growth, or the likelihood of spreading to different sites, or how they respond to treatment. It is very likely that mutations in the gene also cause the tumor to naturally subside.
A rare childhood cancer provides some clues
Neuroblastoma is a rare type of childhood cancer that has the potential to reveal how genetic changes may affect natural regression. In the UK, approximately 100 children are diagnosed with the disease each year, but the disease progresses very different depending on the age of the child. Children with neuroblastoma under the age of 18 can develop tumors with or without any treatment (type 1). However, children over the age of 18 need to receive intensive treatment, but only 40 to 50% survival rate (type 2).
Studies have shown that type 1 neuroblastoma has distinct genetic characteristics relative to type 2 neuroblastoma. For example, this type of tumor usually has a higher level of cellular receptor TrkA, which triggers tumor cell suicide. In contrast, type 2 neuroblastoma has a higher level of another different receptor, TrKB, which makes this tumor more aggressive.
Another possible explanation is that type 1 neuroblastoma exhibits very low telomerase activity relative to type 2 neuroblastoma. Telomerase controls the length of a particular DNA fragment (ie, telomere), which allows tumor cells to continue to divide. In type 1 neuroblastoma, this DNA fragment is very short due to its low telomerase activity and is therefore unstable, triggering tumor cell death.
Epigenetic changes cannot be ruled out. Epigenetic changes do not affect the DNA sequence of the cell, but alter the activity of multiple proteins by chemically labeling different parts of the DNA, such as methylation. Thus, cells with the same DNA sequence but with different chemical markers may make completely different behaviors, causing some tumors to self-destruct. Recent studies have shown that there are significant differences in the genetic markers of type 1 neuroblastoma compared to type 2 neuroblastoma, although these are only preliminary findings.
Although the precise mechanism of tumor regression is still uncertain, it is likely that triggering a strong immune response will definitely play a major role in people with certain genetic traits. Further research on the association between genetic characteristics and triggering immune response will provide an answer to how we can identify tumors with natural regressive capabilities.
The next step is to design a drug that artificially triggers the immune system to specifically target the tumor based on the genetic makeup of the tumor. The development of animal models that mimic the natural regression of human tumors will be a valuable tool for this purpose.