Fudan clarifies the epidemiological characteristics of human infection with avian influenza H7N9 June 08, 2017 Source: Science Network Yu Hongjie, a professor at the School of Public Health of Fudan University, has made significant progress in the field of epidemiological changes and pandemic risk assessment of human infection with avian influenza H7N9. Relevant research results have been published online in the internationally renowned medical journal Lancet Infectious Diseases. (Lancet Infectious Diseases). Since the discovery of the world's first human case of avian influenza H7N9 in March 2013, there has been a wave of human infection with the H7N9 epidemic in winter and spring. The virus can evolve into a virus that causes influenza pandemics through genetic reassortment or adaptive mutations. Continuous virological and epidemiological surveillance and research are important components of pandemic risk assessment. Before the fifth wave of the 2016-2017 epidemic, the H7N9 virus was a low-pathogenic avian influenza virus, and the birds did not develop clinical symptoms after infection with the virus. However, on February 19, 2017, the China CDC reported that the sequencing of the isolates from two human cases of avian influenza H7N9 in Guangdong showed that the virus cleavage site was inserted with multiple basic amino acids, suggesting that The virus has been mutated into a highly pathogenic avian influenza virus, which causes death and death in poultry. In addition, the 2016-2017-fifth epidemic occurred earlier than in previous years, and the number of reported cases exceeded any previous wave. Has the epidemiological characteristics and clinical severity of human infection with avian influenza H7N9 changed in the fifth epidemic? Is the risk of causing a pandemic increased? This has become the focus of the international scientific community and the scientific issues that need to be solved urgently. To this end, the researchers focused on the epidemiological characteristics and clinical severity of the fifth wave of avian influenza H7N9 in 2016-2017 and compared it with the first four waves to reveal whether its epidemiological characteristics, clinical severity and pandemic risk are A change has taken place. The study found that the fifth wave of the 2016-2017 epidemic appeared earlier than in previous years, with a wider geographical spread and more incidence. From the first wave to the fifth wave of epidemics, the proportion of 16-59 years old cases gradually increased from 41% to 57%. The proportion of the fourth and fifth wave of epidemics in urban and rural areas and rural cases (63% and 61%) was higher than the first three waves (39%, 55% and 56%), but the situation in the provinces was not completely consistent. About 70% of cases have a history of poultry exposure 10 days before onset, and live poultry markets and free-range poultry exposure remain the two main routes of infection. Although the case of rural and urban-rural integration reported that the live poultry market was lower than urban cases, 48% of rural cases and 61% of urban-rural outbreaks in the fifth epidemic reported live poultry market exposure. The risk of death, mechanical ventilation and admission to the intensive care unit in H7N9 hospitalized cases is similar to the past. The results of the study indicate that the geographical extent of human infection with avian influenza H7N9 is expanding, suggesting that the geographical spread of the virus among birds is more extensive. As more and more urban live poultry markets close, the virus can spread implicitly along the path of poultry transportation and trading, continuing to spread to areas where there is no or no strict implementation of the live poultry market closure, including areas where the epidemic has not yet been detected. The number of cases reported by the fifth wave of epidemics was higher than the first four waves, suggesting that the circulating intensity of H7N9 virus in poultry may be higher than the previous waves. Experts believe that this study comprehensively clarified the epidemiological characteristics and clinical severity of human infection with avian influenza H7N9 from 2013 to 2017, providing scientific evidence for risk assessment and prevention and control measures for pandemics. The review by the Director of the World Health Organization Animal Influenza Research Reference Center, Richard Webby, an internationally renowned influenza virus expert, and Yang Zifeng, a professor at the First Affiliated Hospital of Guangzhou Medical University, pointed out that Yu Hongjie's research team quickly and comprehensively studied the epidemiological characteristics of avian influenza H7N9. It is proved that the clinical severity of human cases of avian influenza H7N9 has not changed significantly. In response to the “fifth epidemic, the number of cases of avian influenza H7N9 has increased sharply and whether the highly pathogenic H7N9 strain has changed its pandemic. The risk of this key scientific issue. (Reporter Huang Xin correspondent Wang Xiling) anesthesia mask,anesthetic mask,anesthesia gas mask,anesthetic face mask 2 MEDS TECHONOLOGY CO.,LTD , https://www.2-meds.com