Release date: 2017-02-17 According to foreign media reports, the era of "super bacteria" can not end, and humans may have already ordered its life: its secret of drug resistance has been cracked, which opens the door for the development of "superbugs" . Australian scientists have announced that they have found the secret of "super bacteria" in front of drugs, that is, wrapping their layers of protein like armor. Specifically, the molecular structure of this layer of protein is completely drawn. "You can think of this layer of protein as a door lock and a special locking structure inside. If you put this hidden structure in 3D, it is not difficult to find the key to open this lock," Professor Molecular Fleminger (Alice Vrielink) said. She and colleagues at the University of Western Australia cracked the molecular structure of the protein called EptA. In the face of this kind of protein armor protection, the trump card in antibiotics, colistin, can't do anything, and colistin is usually used as a last resort, only if all other treatment attempts fail. Use it. After the molecular structure of this protein armor is broken, humans can polish precision weapons and subdue super bacteria. The most frightening thing about super bacteria is its resistance to chemicals and its ability to keep up with the times. Last spring, the media reported overwhelmingly that the United States discovered an ultra-super bacterium that was strong enough to resist all known antibiotics. Colds and colds add a bit of a tragic color to the end of the world. Scientists call the resistance of germs one of the greatest threats to humans in the 21st century. If this statement is alarmist, the data is not emotional. According to the World Health Organization, at least 700,000 people worldwide die from drug-resistant infections every year. Superbugs have become a paradox in the global health care field and are generally blamed for overuse and even abuse of antibiotics. In order to prevent the "superbug" crisis, some governments, including the United Kingdom, have enacted rules restricting the use of antibiotics. A study has shown that if no measures are taken to allow superbugs to ravage, according to current trends, by 2050, the number of patients dying from drug-resistant infections worldwide will increase by 10 million per year, more than the death of cancer now. Number of people. Evidence from all over the world shows that the trump card in antibiotics, colistin, has already had a strong enemy. This means that there are already some cases of infection in the world that are hopeless. Prof. Flalink's team used X-ray crystallography to create a stereoscopic molecular structure of the EptA protein. If you can try to prevent this protein from covering the bacteria against the human immune system and antibiotics, it will eliminate the anti-drug resistance of super bacteria. She estimates that the next step is to develop drugs to treat superbug infections. It is estimated that two drugs may be needed. First, use a drug to crush the superbug's armor, expose it, and then use the appropriate drugs to kill the bacteria. From revealing the secrets of superbug resistance to clinical applications, it may take several years, she said. The research project led by Professor Flalink is funded by the Australian Government and published in the Proceedings of the National Academy of Sciences. Scientists from several other universities and institutions also participated in the project. Source: China News Network
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