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1. Freeze dryer from the structure of the minute cover type freeze-drying machine: the freeze-drying chamber and the cold trap are separate upper and lower structures, and the freeze-drying chamber has no pre-freezing function. This type of lyophilizer requires manual operation when it is transferred to the drying process after the material has been pre-frozen. Most of the experimental freeze dryers are bell-type, which has a simple structure and low cost. Most of the freeze-drying chambers use a transparent plexiglass cover to facilitate the observation of the lyophilization of the material.
In-situ freeze-drying machine: the freeze-drying chamber and the cold trap are two independent cavities. The shelf in the freeze-drying chamber has a cooling function. After the material is placed in the freeze-drying chamber, the pre-freezing and drying process of the material does not require manual operation. . This type of freeze dryer has a complicated manufacturing process and high manufacturing cost, but the in-situ freeze dryer is the development direction of the freeze dryer, and is an ideal choice for lyophilization process, especially suitable for medicine, biological products and other special products. Freeze-dried.
a, ordinary type b, multi-manifold type c, gland type 2, freeze dryer from the function of ordinary shelf type: material bulk in the material tray, suitable for lyophilization of food, Chinese herbal medicine, powder materials.
With gland type: suitable for the drying of the bottled material of Xilin. When lyophilizing, prepare the material in the vial as needed, float the cap and freeze-dry it. After drying, operate the gland mechanism to compress the cap. It can avoid secondary pollution, re-adsorb moisture, and is easy to store for a long time.
Multi-manifold type: The flask is attached to the outside of the drying chamber, and the material frozen on the inner wall of the bottle is dried. At this time, the flask is connected as a container to the manifold outside the drying box, and the material in the flask is heated at room temperature, and the mixture is heated. The tube switch device can be removed or loaded at any time as needed without stopping the machine.
With pre-freezing function type: material pre-freezing process, cold trap as pre-freezing chamber pre-freezing material, in the drying process, the cold trap is a water trap, capturing the moisture overflowing the material. The lyophilizer with pre-freezing function, the pre-freezing and drying of the materials in the freeze-drying process are all completed on the lyophilizer, and the lyophilizer has high use efficiency, which saves the cost of the low-temperature refrigerator.
Second, several parameters should be paid attention to when purchasing the freeze dryer 1. The number in the freeze-drying machine model represents the freeze-drying area of ​​the freeze dryer. For example, the freeze-drying of the ZX-18 freeze dryer The area is 0.18m2. The user should calculate the lyophilizer for the lyophilized area according to his own needs. For example, for each batch of products that require lyophilization of 1.8 kg (liter) of liquid, and loading the material with a material tray, each loaded with 10 mm thick, the load area of ​​the lyophilized layer can be calculated:
A (area, m2) = V (volume, m3) / H (height, m) = 0.0018 m3 / 0.01 m = 0.18 m2
A lyophilizer with a lamellar load area of ​​0.18 m2 is required.
2, cold trap temperature cold trap is a device for capturing moisture in the freeze-drying process. Theoretically, the lower the cold trap temperature, the stronger the water trap capacity of the cold trap, but the cold trap temperature is low, the refrigeration requirements are high, the machine cost and operation costly. The cold trap temperature of the experimental series of Shanghai Zhixin Freeze Dryer is mainly about -50 °C, -60 °C, -80 °C and so on. Freeze-drying at -50 °C is suitable for some products that are easy to freeze-dry. The freeze-drying machine with a cold trap temperature of -60 °C is suitable for lyophilization of most products, and the freeze-drying temperature is -80 °C. Suitable for lyophilization of some special products. The effect of cold trap temperature on water-trapping capacity shows that the temperature of the cold trap drops from -35 °C to -55 °C, and the water-trapping capacity is obviously improved. The cold trap temperature is lower than -55 °C, and the water trapping capacity of the cold trap is not significantly improved. Therefore, in the absence of special needs, the choice of cold trap temperature -60 ° C is the ideal choice. The cold trap temperature of ZX-1 freeze dryer in Shanghai Zhixin freeze dryer is ≤-50°C, and the cold trap temperature of ZX-18 series and ZX-27 series Shanghai Zhixin freeze dryer is ≤-60°C,-80 °C. And the mixed refrigerant refrigeration technology, in the case of the same refrigeration unit, the refrigeration temperature is low, the cooling capacity is large, the work stability is high, and the failure rate is low. Shanghai Zhixin Freeze Dryer has ZX-1 freeze dryer with cold trap temperature ≤ -50 °C, suitable for lyophilization of some freeze-dried products. The ZX-27 freeze dryer has a cold trap temperature of ≤ -80 ° C and is especially suitable for lyophilization of pharmaceuticals and special products.
3. The cooling rate of the cooling rate reflects the cooling capacity of the refrigeration system. Under no-load conditions, the temperature of the cold trap should reach the minimum temperature specified in the index within one hour. For example, a lyophilizer with a cold trap temperature ≤ -60 ° C, the machine starts from the time of opening the refrigeration, and the cold trap temperature reaches -60 ° C for no more than 1 hour.
4. Ultimate vacuum The ultimate vacuum reflects the leakage of the freeze dryer and the pumping efficiency of the vacuum pump. The degree of vacuum of the freeze-drying box, the past view that the higher the degree of vacuum, the better, the current view that the degree of vacuum should be within a reasonable range. The degree of vacuum is too high, which is not conducive to heat transfer, but the drying speed is reduced, but the vacuum limit of the freeze-drying box should be less than 15Pa.
5, vacuum pumping time The emptying speed of the freeze-drying box should be pumped from atmospheric pressure to 15Pa within half an hour.
6, the layer temperature uniformity and flatness:
The uniformity and flatness of the lamellar temperature have a great influence on the uniformity of product quality. The better the temperature uniformity and the flatness, the better the uniformity of the quality of the freeze-dried product. The lyophilizer shelf temperature control has a heater type and an intermediate fluid type, and the freeze-drying machine shelf with the intermediate fluid control plate layer has uniform temperature uniformity and flatness, and the lyophilizer layer is a hollow sandwich structure, the slab layer The cooling and heating are achieved by circulating the intermediate fluid in the fluid channel inside the ply, so the temperature of the ply is uniform. The ZX-27 freeze dryer in the Shanghai Zhixin freeze dryer uses the technology of the intermediate fluid in the shelf. The shelf temperature control of the bell-type lyophilizer is basically a heater, and the temperature uniformity of the plate layer is slightly poor. However, in general, the temperature difference of the lyophilizer for medical use should be controlled at ±1.5 °C, the temperature difference within the plate is ±1 °C, and the food freeze dryer can be appropriately relaxed.
7. Control system The type and function of the control system of the freeze dryer are different. For the freeze dryer of the experimental series, it is mainly used for the lyophilization process of materials and a small amount of trial production. Therefore, the control system should display the parameters of the freeze-drying process in real time and record automatically; set, modify and effectively execute the freeze-drying process program; have a communication interface to facilitate data collection and storage.
Freeze dryer purchase
I. Experimental series freeze-drying machine classification experiment series The performance indicators of freeze-drying machine are small size, light weight, multi-function, stable performance, high accuracy of test system, preferably multi-purpose for one machine, can adapt to a variety of materials. Freeze-dried experiments. The main division methods of the experimental series of freeze dryers are:
ZX-27(S)
ZX-27/27S series freeze dryer
A freeze dryer is a technical method of preliminarily freezing an aqueous article and then sublimating the water under vacuum to obtain a dried article. The freeze-dried articles are easy to store for a long time, and can be restored to the state before lyophilization and maintain the original biochemical characteristics after adding water. For heat sensitive substances such as antibiotics, vaccines, blood products, enzyme hormones and other biological products, freeze drying technology can show its superiority.
ZX series freeze dryer adopts air-cooled condensing refrigeration system, stainless steel structure and transparent drying chamber, which is convenient for observing the whole process of freeze-drying.
The S series in the ZX series has the programmable heating control function of the shelf, adopts PID adjustment, precise temperature control, and the human-machine interface adopts a large-screen LCD screen, which is provided with curves and data, and provides users with more information about the freeze-drying process. More information, and equipped with a host computer communication interface.
It is a medium-sized vertical freeze-drying device with larger freeze-drying area, suitable for freeze-drying test and small batch production of laboratory samples.
ZX-27S series freeze-drying machine is reinforced, with partition heating function, large-screen LCD touch screen, programmable control and memory freeze-separator temperature curve and sample temperature curve. PID adjustment, precise temperature control, in the form of curves and data, at the same time provide users with more information about the freeze-drying process, and with a host computer communication interface, can be connected to the computer.
This series is divided into: ordinary type, gland type, multi-tube type common type, multi-tube type gland type (S type is LCD touch screen separator program heating)
ZX-27 common type ZX-27 gland type ZX-27 multi-manifold ZX-27 multi-manifold gland type
ZX-27S common type ZX-27S gland type ZX-27S multi-manifold ZX-27S multi-manifold gland type
Technical Parameters:
â– Cold trap temperature: -80 o C (when no load)
■Ultimate vacuum: ≤13Pa (when no load)
■Cooling time: ≤120min
■Maximum vacuum time: ≤20min
â– Water catching capacity: 10Kg/24h
â– Freeze-dried area: 0.13-0.27 m2;
■Material tray specifications: 6 types of common type Φ240mm, freeze-drying area: 0.27m 2 , 558 bottles with a diameter of 22mm can be placed
Gland type Φ220mm total 3 layers, freeze-drying area: 0.135m 2 , 250 bottles with a diameter of 22mm
â– Shelf heating programmable control, using a large screen LCD screen, providing more information about the freeze-drying process in both curves and data;
â– Machine power consumption: about 1700VA
■Mainframe dimensions (length × width × height): 1000mm × 555mm × 780mm (excluding drying room)
â– Applicable power supply: 220V 50Hz
Note: The cold trap of this machine also serves as the pre-freezing chamber. The shelf heating is programmable and the LCD screen displays the freeze-drying curve.
This series is an ultra-low temperature in-situ automatic control freeze dryer for lyophilization or small-scale production of laboratory samples.
This series is divided into: ordinary type, gland type