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Alias ​​entecavir hydrate, entecavir monohydrate, the latest anti-hepatitis B virus first-line drugs. Entecavir is a cyclopentanoguanyl analog. Phase II/III clinical studies have shown that 0.5 mg orally daily by adults is effective in inhibiting HBV-DNA replication and is superior to lamivudine; phase III clinical studies have shown that it is effective to increase the dose to 1 mg daily for those who develop YMDD mutations. Inhibits HBV DNA replication. The incidence of drug resistance at the first year of treatment for untreated patients was zero, but the incidence of drug resistance at one year of treatment for patients with YMDD mutations was 5.8%. China's SFDA has also been approved for the treatment of patients with chronic hepatitis B.